6 Great Health Benefits of Black Seeds Oil for Diabetics

Black seeds health benefits work for diabetes and many other health problems


Anti Diabetic Properties


Black seeds brings health benefits beyond just lowering blood sugar. Black seeds improve a variety of health conditions that can lead to diabetes. Black seeds effectiveness in combating diabetes addresses the cause of diseases rather than just masking symptoms.

#1 Pancreatic protective activity

Black seeds oil or extract was shown to decrease oxidative stress thus preserving pancreatic β-cell integrity. The amelioration of β-cell structure could be evidenced by an increase of insulin levels in a study using laboratory rats. Oral administration of thymoquinone (most abundant compound in Black seeds) 20 – 80 mg/kg (body weight) for 45 days have been shown to improve glycemic status in induced diabetic rats. In addition, a significant decrease in glucose and HbA (1C) levels were noted. Altered carbohydrate metabolic enzymes were also restored to near normal.

#2 Anti oxidant activity

Thymoquinone has been shown to suppress oxidative stress and renal proliferation of carcinogenesis in lab rats. It is likely that thymoquilone can inhibit oxidative stress caused by oxidized hydrogenated oils, something so common in our present diet. Black seeds when used for 6 weeks prevents oxidative stress in the liver by increasing the activity of enzymes such as myeloperoxidase, glutathione-S-transferase, CAT, adenosine deaminase, myeloperoxidaseand bydecreasing hepatic lipid peroxidation.

#3 Anti-inflammatory activity

Black seed extract was found in a study to have anti-inflammatory and analgesic properties. In a animal model study, inflamed glial cells (cells from the neural system thus vulnerable to diabetes inflammatory process) were tested with black seed leaf extract. A significant inflammatory reduction was noted in these cells after 0.2 to 1.6 mg/mL of black seed extract from the seeds were administered.


#4 Cardiovascular activity

Black seeds extract is a potent cardiovascular protector. It works by reducing systemic inflammation. In a study, laboratory rats were exposed to heavy doses of diesel exhaust particles. This exposure have created lung inflammation and reduced systolic blood pressure. The diesel exhaust intoxication was designed in order to simulate platelets aggregation and cardiovascular impairment. The use of Black seed extract have restore blood pressure to normal levels and reduced leukocytosis which is a hallmark of inflammation, atherosclerosis (hardening of the arteries) and  heart disease.

#5 Kidney protective activity

Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. Oxidative stress also aggravates kidney disease one of the main complication of diabetes. Nigella sativa oil help lowering the high levels of Serum Creatinine and BUN and increased serum antioxidant activity protecting and reversing kidney disease.


#6 Hepato protective activity

In one study it was shown that Black seed oil relives the effects of injury to the liver. It protects the liver also from the toxic effects of lead and attenuate hepatic lipid peroxidation. Treatment with the oil resulted in a significant increase in antioxidant enzymatic activities.

Black seeds is a small plant that grows up to 20 – 90 cm tall, its leafs are fine and long resembling branches of a miniature tree. The flowers and pods are markedly beautiful with an unusual shape. Its flowers can be white, yellow, pink, pale blue, or pale purple and are strikingly bright.

Common Names: black seeds, fennel flower, nutmeg flower, black caraway, Roman coriander Latin Name: Nigella sativa

About this plant

nigella-sativa-seed-pod.jpgThe pods are shaped like unions or small inflated balloons or capsules changing from green to pale violet. These capsules are divided in 3 – 7 united follicles, each housing numerous seeds. The seeds are small and angular measuring about 2 – 3.5 mm, black externally and white inside with an odor slightly aromatic and bitter taste. Don’t confuse black seeds with black chia seeds; they are different plants.

Available Forms
  • Seeds
  • Cold pressed seed oil
  • oil in softgel
The seeds and their oil have been used for centuries in the treatment of many health problems and have an important historical and religious past. It is an important medicine in the Unani and Ayurveda medicine. It is considered a great healing herb among Muslims. From the Prophetic hadith “black seeds is the remedy for all diseases except death”. Nigella sativa is native of Southern Europe, North Africa, and Southwest Asia, and it is cultivated throughout the Middle Eastern Mediterranean region, India, Pakistan, Syria, Turkey, Saudi Arabia.

Other Medicinal Properties

The most important compounds in black seeds are:
  • Thymoquinone (30% – 48%)
  • thymohydroquinone
  • dithymoquinone
  • p-cymene (7%-15%)
  • carvacrol (6%-12%)
  • 4-terpineol (2%-7%)
  • t-anethol (1%-4%)
  • sesquiterpene longifolene (1%-8%)
  • α-pinene
  • thymol

Black seeds also contain compounds in trace amounts:

  • Isoquinoline alkaloids
  • nigellicimine
  • nigellicimineN-oxide
  • pyrazol alkaloids
  • nigellidine
  • nigellicine

In addition, black seeds also contain alpha-hederin, a water soluble pentacyclic triterpene and saponin, a potential anticancer agent. Black seeds have been mostly used as an anti-hypertensive, diuretic, anti-diarrheal, liver tonic, appetite stimulant, analgesics, skin disorders, and anti-bacterial. Extensive studies have also concluded that a wide range of pharmacological actions are possible including: anti-diabetic, immunomodulator, antimicrobial, anticancer, anit-inflammatory, spasmolytic, bronchodilator, gastro-protective, and antioxidant. These benefits can be attributed in great part by the therapeutic properties of thymoquinones; a major component of the essential back seed oil.

How to Use it
Black seeds as with most other herbs have better results when used in extracts and oils rather then using the actual plant. As with any herbs, experimentation is important because it is hard to be sure of specific measurements. Herbs are not controlled as traditional medications are.
Even though studies do point out to specific mg dosages, they have been only evaluated in laboratory rats. Safer is to follow the recommendation on the oil or supplements you buy and monitor the effects as you start with lower doses and progress to larger. Everyone is different and absorb compounds differently, and the products you buy might have different degree of potency, so experimentation is key.


Precautions and possible interactions

 Black seed oil or capsule has no known side effects. Caution is necessary only if you are using very high dosages. Three oil tablespoons a day may be safe dosage, start for a few days and then go up to 2 or 3. Don’t take black seed oil on a full stomach. For better results mixed it with another liquid. Most people mix it with honey or juice, but if you are diabetic you might want to mix it with yogurt and take it one hour before a meal. If you eat the seeds never eat them without heating, they might cause upset stomach. Ideally if you have one of those cast iron pans or similar, roast them on a high fire for a few minutes.
other precautions are:
  • Don’t use back seeds if you are pregnant, black seeds can slow down or stop uterus contractions. There might be some issues with breast feeding as well
  • If you have low blood pressure issues you should avoid black seeds as it can lower blood pressure
  • Avoid mixing with other medications specially blood thinners such as warfarin, coumadin, and aspirin
  • Avoid altogether if you have any bleeding disorder. Black seed can make bleeding disorder worse
  • Diabetics should be extra careful when taking black seeds because it will lower blood glucose, so if you are taking glucose lowering drugs, such as metformin, glipizide, or insulin it might lower your blood sugar to dangerous levels
  • If you are going to have surgery stop taking black seeds at least two weeks prior to surgery. It might increase the chance of bleeding, it can increase sleepiness, and it might interfere with blood sugar control in anesthesia during and after surgery.




  1. Partial Regeneration/Proliferation of the beta-Cells in the Islets of Langerhans by ts in Nigella sativa L L.in Streptozotocin-Induced Diabetic Rats
  2. Biochemical effects of Nigella sativa L seeds in diabetic rats
  3. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
  4. A review on therapeutic potential of Nigella sativa: A miracle herb
  5. Antibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. and Their Interaction with Some Antibiotics
  7. Oxidative stress and diabetic complications
  8. Blood Glucose Lowering Effects of Nigella Sativa L. Seeds Oil in Healthy Volunteers: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

You comments are very important

Please leave a comment if you think this site was helpful to you. Let me know if there is any other area of diabetes treatment you would like to see covered in future posts. If you used any of the herbal treatments covered in this site, please let others know if you had any results, or what aspects of it worked better for you. Your input could help others and also make this site a stronger resource for people trying to treat diabetes naturally.

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Image credits: Flickr.com 1, 2, 3, 4, 5, 6



Meet the Author

Marcos Taquechel

Hello. I hope you enjoyed this article. Your comments are very important.

9 comments… add one
  • pam May 11, 2017, 7:17 pm

    Hello, I started taking BSO 3 days ago. I have low thyroid which can cause low bloodsugar. I have taken before bed and woke up dizzy, tired and not feeling well. I have also taken in morning and about an hour later don’t feel normal. Do you suppose it is lowering my blood sugar? Maybe take the dose at noon after I am up and running. Would this be a safe protocol. I really want to take advantage of the benefits of BSO. Thank-you for your answer.

    • Marcos Taquechel May 12, 2017, 12:46 am

      The only way to find out is to check your BS. You should also take BSO with meals because it can upset your stomach. Try different doses, start with small doses like 1/2 tbs and then increase. BSO is strong so be careful. I didn’t feel so great the first time I used it. Good luck

  • Gururaj Jahagirdar Feb 13, 2017, 8:23 am

    My wife is of hypothyroids since last 6 yrs.Now she is on Allopathy treatment.As I got good result for my Diabetic II,I want to try Nagella Sativa seed oil to my wife she is 59 yrs Kindly advise the dose & the fruit juice/honey & how long to take treatment

    • Marcos Taquechel Feb 13, 2017, 9:54 am

      I’m assuming your wife has diabetes type II. Nagella sativa oil is a great medicine and very powerful. As with any herbs experimentation is the most important. It is very difficult to give precise instructions on dosage and use. Herbal products are not regulated as traditional medicine is. The same is true for medicinal plants too; some will work better then others depending on each individual. So my advice is to start with small doses and observe the results, if no results then increase the dosage. The videos also give you some tips on how to use. Also read the paragraph “how to use it” in the post.

  • Denise and Bob Jun 23, 2016, 11:14 am

    thanks so very much, loved the reference material, just took my first low dose black seed yesterday, thanks again

  • jocelyn May 31, 2015, 7:42 am

    Wow! I never knew black seeds have so much health benefits. Truly, it is one of Mother Nature’s greatest wonders 🙂 Thanks for sharing this post.

    • DiabetesReviewer May 31, 2015, 11:48 am

      I’m glad you liked. It is also an amazing looking flower, I’m trying to grow it in my garden

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